منابع مشابه
Cellular and molecular basis of epilepsy.
The epilepsies comprise a remarkably diverse collection of disorders that affect 1% of the population in the United States (Hauser and Hesdorffer, 1990). Current therapy is symptomatic. Available drugs reduce seizure frequency in the majority of patients, but only 40% are free of seizures despite optimal treatment (Elwes et al., 1984; Mattson et al., 1985). Neither an effective prophylaxis nor ...
متن کاملMolecular and cellular basis of epileptogenesis in symptomatic epilepsy.
Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a cascade of molecular and cellular changes that eventually lead to the occurrence of spontaneous seizures. Cellular alterations include neurodegeneration, neurogenesis, axonal sprouting, axonal injury, dendritic remodeling, gliosis, invasion of inflammatory cells, angiogenesis, alterations in extracellular m...
متن کاملMolecular basis of inherited epilepsy.
E pilepsy is a common, paroxysmal, and heterogeneous neurological disorder. Many factors, including complex genetic influences, contribute to the pathogenesis of epilepsy. However, several epilepsy syndromes are caused by mutations in single genes (Table). Most epilepsy-associated genes that have been identified within the past 5 years encode ion channels. This review illustrates the progress i...
متن کاملMolecular Basis of an Inherited Epilepsy
Epilepsy is a common neurological condition that reflects neuronal hyperexcitability arising from largely unknown cellular and molecular mechanisms. In generalized epilepsy with febrile seizures plus, an autosomal dominant epilepsy syndrome, mutations in three genes coding for voltage-gated sodium channel alpha or beta1 subunits (SCN1A, SCN2A, SCN1B) and one GABA receptor subunit gene (GABRG2) ...
متن کاملCellular and molecular basis of decision-making.
People think they are in control of their own decisions: what to eat or drink, whom to marry or pick a fight with, where to live, what to buy. Behavioural economists and neurophysiologists have long studied decision-making behaviours. However, these behaviours have only recently been studied through the light of molecular genetics. Here, we review recent research in mice, Drosophila melanogaste...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1994
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.14-06-03413.1994